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I am having trouble to find out how to filter users in a list.
For example, my main list has 20 mil subscribers, but not all of them are active (they don´t open emails anymore, at least mine). Sometimes, it is important to send them emails, however most of time I would just send emails to active users (those that open emails and click).
How can I separate active users?
You can export CSVs of users who "opened" or "clicked" in your last report. Then import them into a new list.